abstract：:Cells bearing the gamma delta form of the TCR make up only 1-3% of T cells in the adult murine thymus and peripheral lymphoid organs. Evidence from studies of nude mice suggests that the development of at least some gamma delta T cells is thymus dependent; however, until now it has not been directly demonstrated that ...

journal_title：International immunology

authors： Kelly KA,Pearse M,Lefrancois L,Scollay R

更新日期：1993-04-01 00:00:00

abstract：:Recombination activating genes Rag-1 and Rag-2 were isolated on the basis of their ability to confer V(D)J recombination activity when co-expressed in fibroblasts. The mode of action of the confer V(D)J recombination activity when co-expressed in fibroblasts. The mode of action of the products of these genes is not kn...

journal_title：International immunology

authors： Kallenbach S,Brinkmann T,Rougeon F

更新日期：1993-02-01 00:00:00

abstract：:Based on the similarity in primary structure between the newly characterized ligand for CD40 (CD40L) and the tumor necrosis factors (TNFs), we have modeled a detailed 3-D structure for CD40L. We used the known structure of TNF alpha as a template for the generation of the CD40L model. The soundness of the model-buildi...

journal_title：International immunology

authors： Peitsch MC,Jongeneel CV

更新日期：1993-02-01 00:00:00

abstract：:The specificity of self MHC-restricted T cells responding to peptide fragments of processed antigen has been well characterized. However, the means by which alloreactive T lymphocytes recognize MHC alloantigen remain poorly understood. We now provide evidence that the recognition of class I human leukocyte antigen (HL...

journal_title：International immunology

authors： Breur-Vriesendorp BS,Ivanyi P

更新日期：1993-01-01 00:00:00

abstract：:Cyclosporin A (CsA) prevents most immature thymocytes from progressing to a mature phenotype and blocks the deletion of T cells that express self-specific TCR in the small population of cells that achieve maturity. The latter effect may explain the paradoxical observation that this immunosuppressive drug can induce au...

journal_title：International immunology

authors： Urdahl KB,Pardoll DM,Jenkins MK

更新日期：1992-12-01 00:00:00

abstract：:We have previously shown that the occurrence of CD45RA+ adult mouse thymocytes is strain-dependent, e.g. constituting approximately 0.6% in C57BL/Icrf and approximately 2.5% in BALB/c (Huby, R. and Goff, L., 1992. Eur. J. Immunol. 22:1659). Here we show that irrespective of strain, the thymus contains approximately 0....

journal_title：International immunology

authors： Goff LK,Huby RD

更新日期：1992-11-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired type hemolytic disorder. Hematopoietic cells of patients with PNH are deficient in glycosylphosphatidylinositol (GPI) anchored membrane proteins. Since some membrane-bound complement inhibitors, such as CD59 and decay accelerating factor (DAF), are GPI anchored ...

journal_title：International immunology

authors： Ueda E,Nishimura J,Kitani T,Nasu K,Kageyama T,Kim YU,Takeda J,Kinoshita T

更新日期：1992-11-01 00:00:00

abstract：:Although IL-2 receptor beta chain (IL-2R beta) expressed in various lymphoid cell lines binds IL-2 with an intermediate affinity, IL-2R beta expressed in fibroblasts is unable to bind IL-2, suggesting that IL-2R beta is on its own not sufficient for generating the intermediate-affinity receptor and that lymphoid-speci...

journal_title：International immunology

authors： Kuida K,Tanaka T,Kitamura F,Toyama-Sorimachi N,Miyasaka M

更新日期：1992-10-01 00:00:00

abstract：:Antibody responses to ingested antigens can be inhibited by a mechanism known as oral tolerance which acts to prevent excessive stimulation from luminal contents. Local IgA responses can be induced in this non-responsive environment and during intestinal inflammation, mucosal IgG responses can also be increased. The p...

journal_title：International immunology

authors： Zettel L,Clark DA,Ernst PB

更新日期：1992-09-01 00:00:00

abstract：:We report the characterization of the Fc epsilon RI gamma chain which associates with the transmembrane form of CD16 to form the low affinity receptor for IgG (Fc gamma RIII) expressed on human natural killer (NK) cells. cDNA cloning and sequence analysis of Fc epsilon RI gamma from a polyclonal CD3-CD16+ NK line esta...

journal_title：International immunology

authors： Moingeon P,Lucich JL,Reinherz EL

更新日期：1992-08-01 00:00:00

abstract：:T lymphocyte responses to the MHC of an evolutionarily distant species are known to be weak compared with responses against allogeneic MHC products within a species. This fact was used to examine the regions of human MHC class II molecules required for the stimulation of strong primary immune responses against MHC all...

journal_title：International immunology

authors： Ramesh P,Barber L,Batchelor JR,Lechler RI

更新日期：1992-08-01 00:00:00

abstract：:'Programmed cell death' has been used to describe the death of cells killed by cytotoxic T cells or growth factor deprivation. Although bcl-2 can prevent death of cells deprived of growth factor, it failed to protect cells against T cell killing. In spite of bcl-2 expression, the DNA of targeted cells was degraded int...

journal_title：International immunology

authors： Vaux DL,Aguila HL,Weissman IL

更新日期：1992-07-01 00:00:00

abstract：:J11d is expressed on a variety of hemopoietic cells, including B cells. In previous studies, we have shown that B cells are heterogeneous with respect to their levels of J11d expression and that memory B cells are contained within the J11dlo B cell population. In this report, we have further examined the relationship ...

journal_title：International immunology

authors： Yin XM,Vitetta ES

更新日期：1992-06-01 00:00:00

abstract：:Structural and functional aspects of the accessory molecule lymphocyte function associated antigen (LFA)-3 (CD58) have been examined following the transfection of DAP.3 and P815 cells with a cDNA clone encoding the glycosyl phosphatidylinositol (GPI)-linked form of human LFA-3. Despite earlier observations that DAP.3 ...

journal_title：International immunology

authors： Greenlaw R,Robinson P,Heaton T,Lombardi G,Lechler R

更新日期：1992-06-01 00:00:00

abstract：:In this paper we describe a monoclonal antibody, JR9-318, which was obtained from a wild-derived mouse immunized with the M14T cell line (CD3+CD4-CD8-) in order to describe antigenic molecules expressed during T cell differentiation. This mAb precipitated a protein from the M14T cell line or subclones that migrates li...

journal_title：International immunology

authors： Roland J,Cazenave PA

更新日期：1992-06-01 00:00:00

abstract：:A subclone (160b) of the human B cell (Karpas 160) was shown to produce a novel cytotoxic lymphokine [Factor 2 (F2)] in addition to tumour necrosis factor alpha (TNF-alpha) and beta (TNF-beta). F2 was found to have selective toxicity to numerous human tumour cell lines, particularly the erythroleukaemic cell line K562...

journal_title：International immunology

authors： Ni J,Meager A,Karpas A

更新日期：1992-04-01 00:00:00

abstract：:An alloreactive CTL clone, 27.B2, produced in the mouse strain combination B6.C-H-2bm1 (bm1) against C57BL/6 (B6) and nominally directed against the Kb molecule has been shown to be peptide dependent. The clone recognizes intact B6, but not intact bm1 or bm3 target cells. However, peptides recognized by 27.B2 CTL can ...

journal_title：International immunology

authors： Falk K,Rötzschke O,Rammensee HG

更新日期：1992-03-01 00:00:00

abstract：:A Plasmodium falciparum schizont lysate has been previously described as being a powerful inducer of proliferation for human peripheral T lymphocytes. In this report we study the phenotype of cycling T cells from unexposed donors and examine how the P. falciparum lysate compares with the conventional T cell mitogen ph...

journal_title：International immunology

authors： Behr C,Dubois P

更新日期：1992-03-01 00:00:00

abstract：:Incompatibility of human minor histocompatibility (hmH) antigens induces rejection of grafts in organ transplantation and graft versus host disease in bone marrow transplantation if donor and recipient are matched for human leukocyte antigen (HLA) genes. These antigens are recognized only by T cells. We describe here ...

journal_title：International immunology

authors： Sekimata M,Griem P,Egawa K,Rammensee HG,Takiguchi M

更新日期：1992-02-01 00:00:00

abstract：:In view of our recent report that T cell receptor (TCR) alpha chain restriction fragment length polymorphism (RFLP) is associated with multiple sclerosis (MS), we have assessed the possibility that HLA-DR2, HLA-DPw4, and TCR alpha chain RFLPs may interact to increase the risk of developing MS. Detection of TCR alpha c...

journal_title：International immunology

authors： Sherritt MA,Oksenberg J,de Rosbo NK,Bernard CC

更新日期：1992-02-01 00:00:00

abstract：:BALB/c mice injected at birth with 10(8) semi-allogeneic (C57BL/6 x BALB.IgHb)F1 spleen cells develop a lupus-like syndrome in which autoantibodies bear exclusively the donor allotype. We have analyzed the evolution of donor B cell chimerism and the autoimmune manifestations during the first year of life in these mice...

journal_title：International immunology

authors： de la Hera M,de la Hera A,Ramos A,Buelta L,Alonso JL,Rodriguez-Valverde V,Merino J

更新日期：1992-01-01 00:00:00

abstract：:It has proven difficult to evaluate the functional potential of germinal center (GC) B cells, including those from Peyer's patches (PP), by either in vivo or in vitro methods. Thus, rather than assess secreted Ig product as an indicator of functional potential we have instead sought to detect mRNAs related to the vari...

journal_title：International immunology

authors： Weinstein PD,Schweitzer PA,Cebra-Thomas JA,Cebra JJ

更新日期：1991-12-01 00:00:00

abstract：:It was recently shown that paf-acether (paf) synthesized in different cell types remains partly cell-associated. In the present work, we tested the hypothesis that cell-associated paf might in fact remain exposed on the external plasma membrane and be able to exert its biological functions. Human polymorphonuclear neu...

journal_title：International immunology

authors： Ninio E,Leyravaud S,Bidault J,Jurgens P,Benveniste J

更新日期：1991-11-01 00:00:00

abstract：:Interleukin 3 (IL-3) promotes the survival and proliferation of hematopoietic cells of various lineages in culture. Like most other hematopoietic colony stimulating factors, its mode of action is unknown. However, binding of the lymphokine induces protein tyrosine phosphorylation and enhanced glucose transport in some...

journal_title：International immunology

authors： Nefesh I,Bauskin AR,Alkalay I,Golembo M,Ben-Neriah Y

更新日期：1991-08-01 00:00:00

abstract：:pp56lck is a member of the src family of tyrosine kinases mainly expressed in T lymphocytes. Src tyrosine kinases have been implicated in the control of cell growth and differentiation in different cell types, but the mechanism of regulation of these enzymes is poorly understood. In order to characterize the distinct ...

journal_title：International immunology

authors： Carrera AC,Li P,Roberts TM

更新日期：1991-07-01 00:00:00

abstract：:Naive and primed alpha beta T cells can be distinguished on the basis of their differential expression of CD45RA and CD45RO, respectively. The present study indicates that these CD45-isoforms also identify naive and primed maturational stages of gamma delta T cells and natural killer (NK) cells. In peripheral blood, a...

journal_title：International immunology

authors： Braakman E,Sturm E,Vijverberg K,van Krimpen BA,Gratama JW,Bolhuis RL

更新日期：1991-07-01 00:00:00

abstract：:In this study we investigated the role of the invariant chain (li) in the presentation of hen egg lysozyme (HEL) and measles virus hemagglutinin (HA) antigens to MHC class II-restricted T hybridoma cells. Fibroblastic cells transfected with Ed or Ak genes, and supertransfected or not with the li gene, were used as ant...

journal_title：International immunology

authors： Bertolino P,Forquet F,Pont S,Koch N,Gerlier D,Rabourdin-Combe C

更新日期：1991-05-01 00:00:00

abstract：:Activated macrophages exert strong arginase (ASE) activity that converts L-arginine into ornithine, the key precursor for putrescine and polyamine biosynthesis. Macrophages were previously also shown to generate nitric oxide that is derived from the guanido group of arginine by the oxidative deiminase (OAD) reaction. ...

journal_title：International immunology

authors： Benninghoff B,Lehmann V,Eck HP,Dröge W

更新日期：1991-05-01 00:00:00

abstract：:HIV infected T and monocytic cell lines could activate and fix C3 fragments when incubated in human serum under conditions allowing for activation of the alternative complement pathway. Normal T lymphocytes incubated with HIV could also activate and fix C3. This activity was, at least in part, the property of the viru...

journal_title：International immunology

authors： Yefenof E,Asjö B,Klein E

更新日期：1991-04-01 00:00:00

abstract：:The distribution of IgE FcR (Fc epsilon R)-positive and -negative B cells was examined in normal adult mice. Using three-color flow cytometry, the expression of the Fc epsilon R was analyzed on various B-cell subsets present in the peritoneum and spleen. The results demonstrate that in the peritoneal cavity, the Fc ep...

journal_title：International immunology

authors： Waldschmidt TJ,Kroese FG,Tygrett LT,Conrad DH,Lynch RG

更新日期：1991-04-01 00:00:00

abstract：:The human IL-3 gene, located on chromosome 5, contains several cis-acting DNA sequences, i.e. CLE (conserved lymphokine element) and a GC-rich region, similar to the GM-CSF gene. To investigate the role of these elements, the 5' flanking region of the IL-3 gene was attached to a bacterial chloramphenicol acetyltransfe...

journal_title：International immunology

authors： Nishida J,Yoshida M,Arai K,Yokota T

更新日期：1991-03-01 00:00:00

abstract：:We have previously cloned the murine homolog of cDNA for the human myelomonocytic differentiation antigen, CD14. We synthesized three hydrophilic peptides derived from the predicted amino acid sequence of murine CD14 (mCD14), designated MS7.1, MS7.2, and MS7.3, respectively, and raised antisera against them. Each anti...

journal_title：International immunology

authors： Nasu N,Yoshida S,Akizuki S,Higuchi Y,Setoguchi M,Yamamoto S

更新日期：1991-02-01 00:00:00

abstract：:Using anti-Tac (anti-alpha chain) and 2R-B (anti-beta chain) antibodies, we studied the roles of IL-2 receptor subunits (alpha and beta chains) in the formation of IL-2 and high-affinity IL-2 receptor complex, which is the initial event of IL-2 induced T cell growth. High-affinity IL-2 binding which was undetectable i...

journal_title：International immunology

authors： Kamio M,Uchiyama T,Arima N,Itoh K,Ishikawa T,Hori T,Uchino H

更新日期：1990-01-01 00:00:00

abstract：:Amongst CD4-CD8- (double negative) thymocytes there is a sizeable population (variable from strain to strain) of cells expressing surface T cell receptor (TCR). These TCR+ double negatives are predominantly non-cycling, have very little precursor activity, and, unlike the TCR-CD4-CD8- thymocytes, appear not to be part...

journal_title：International immunology

authors： Wu L,Pearse M,Egerton M,Petrie H,Scollay R

更新日期：1990-01-01 00:00:00

abstract：:The contribution of the HLA-DRB1, -B3, and -B5 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T cells isolated from an atopic individual (HLA-DRw12, DR7; DRw52b) with perennial rhinitis was investigated. Using a panel of histocompatible and histoincompatible accessory cells, the ...

journal_title：International immunology

authors： O'Hehir RE,Mach B,Berte C,Greenlaw R,Tiercy JM,Bal V,Lechler RI,Trowsdale J,Lamb JR

更新日期：1990-01-01 00:00:00

abstract：:cDNA clones which strongly hybridized with a 3.1 kb mRNA from mouse macrophages and macrophage cell lines and weakly with mRNA from P815 but not from a variety of other cell lines and tissues were isolated from cDNA libraries constructed using mRNA from murine macrophage cell lines and peritoneal macrophages. Treatmen...

journal_title：International immunology

authors： Yoshida S,Setoguchi M,Higuchi Y,Akizuki S,Yamamoto S

更新日期：1990-01-01 00:00:00

abstract：:Lymphokine activity in seven myelin basic protein (MBP)-specific T cell clones was examined. All of the clones recognize MBP peptide 1-9 in the context of I-Au. A strong positive correlation was found between levels of lymphotoxin (LT) and tumor necrosis factor alpha (TNF-alpha) mRNA and biological activity on L929 ce...

journal_title：International immunology

authors： Powell MB,Mitchell D,Lederman J,Buckmeier J,Zamvil SS,Graham M,Ruddle NH,Steinman L

更新日期：1990-01-01 00:00:00

abstract：:Earlier studies have suggested that in adults the n-positive allele of the human IgG2 gene is more productive than the n-negative allele. This superiority was seen to be manifested in IgG2 antibody responses to polysaccharides, in the higher serum concentration of total IgG2 in the n/n than in -/- individuals, and in ...

journal_title：International immunology

authors： Sarvas H,Rautonen N,Käyhty H,Kallio M,Mäkelä O

更新日期：1990-01-01 00:00:00

abstract：:We have investigated the B cell response to Mycobacterium leprae in leprosy patients and healthy controls. A comparison of Western-blotted proteins separated by two-dimensional gel electrophoresis and probed with pooled sera from LL and BT patients revealed distinct antigen recognition patterns for the two classificat...

journal_title：International immunology

authors： Mahon AC,Gebre N,Nurlign A

更新日期：1990-01-01 00:00:00

abstract：:CD4 and CD8 T cell subsets involved in primary allo-MLR responses were re-evaluated in the present study. The slope analysis of B6 allo-MLR responses to MHC class I-disparate bm1 and class II-disparate bm12 revealed the presence of a T-T cell interaction between CD4 and CD8 T cell subsets. The allo-MLR response of B6 ...

journal_title：International immunology

authors： Asano Y,Komuro T,Tada T

更新日期：1990-01-01 00:00:00